01 - In a large bowl, whisk together olive oil, lemon juice, Cajun seasoning, smoked paprika, garlic powder, onion powder, thyme, oregano, salt, black pepper, and cayenne pepper until fully combined.
02 - Add the shrimp to the bowl and toss thoroughly to coat evenly with the spice mixture. Cover and refrigerate for 20 minutes to allow flavors to penetrate.
03 - Preheat a grill or grill pan to medium-high heat. If using wooden skewers, soak them in water for 20 minutes to prevent burning during cooking.
04 - Thread the marinated shrimp onto skewers, piercing through both the head and tail sections for secure handling on the grill.
05 - Grill the shrimp for 2–3 minutes per side until they turn opaque throughout and develop slight char marks. Be careful not to overcook as shrimp become rubbery.
06 - Remove from the grill and transfer to a serving platter. Sprinkle with fresh chopped parsley and arrange lemon wedges alongside for squeezing.