01 - Heat a large skillet over medium-high heat. Add the ground beef, salt, pepper, smoked paprika, and garlic powder. Break up the meat with a spatula and cook, stirring occasionally, until browned and cooked through, about 7-8 minutes. Drain excess fat if needed.
02 - While the beef cooks, whisk together the mayonnaise, ketchup, mustard, pickle relish, apple cider vinegar, smoked paprika, salt, and pepper in a small bowl until smooth and well combined. Set aside.
03 - Divide the chopped romaine lettuce evenly among four large serving bowls, creating a bed of greens for each portion.
04 - Top each lettuce bed with equal portions of the cooked ground beef, cherry tomatoes, shredded cheddar cheese, red onion slices, pickle slices, and diced avocado.
05 - Drizzle the prepared burger sauce generously over each bowl. Serve immediately while the beef is still warm.